肺炎衣原体感染与肺癌发病关系

目的 探讨肺炎衣原体（Cpn）感染与肺癌发病的关系，为肺癌的预防控制提供参考依据。方法 采用以医院为基础病例对照研究方法收集2012年6月—2013年1月在福建医科大学附属第一医院、协和医院和南京军区福州总医院就诊的185例新发肺癌患者及同期在此3家医院进行健康体检和在骨科、眼科就诊的190例非肿瘤患者进行问卷调查，并采用微量免疫荧光法检测Cpn感染情况。结果 病例组Cpn IgG和IgA抗体阳性率分别为59.46%和26.49%，均高于对照组的34.21%和6.84%，差异均有统计学意义（P<0.05）；调整性别、年龄、文化程度、职业、婚姻状况、体质指数后，Cpn IgG抗体滴度为1：64~1：512和≥1：512者肺癌的发病风险分别为IgG抗体滴度<1：64者的2.44倍（OR=2.44，95%CI=1.56~3.81）和7.64倍（OR=7.64，95%CI=1.57~37.25），Cpn IgA抗体滴度为1：32~1：64者肺癌的发病风险为IgA抗体滴度<1：32者的3.79倍（OR=3.79，95%CI=1.88~7.65）；Cpn感染和环境因素对肺癌发病风险的联合作用分析结果表明，Cpn IgG、IgA与吸烟、环境烟草烟雾暴露、肺部炎症性疾病、癌症家族史均存在协同作用（P均<0.05）。结论 Cpn感染与人群肺癌发病有关，Cpn IgG、IgA与吸烟、环境烟草烟雾暴露、肺部炎症性疾病、癌症家族史均存在协同作用。

Association of Chlamydia pneumoniae infection with risk of lung cancer

Objective To investigate the relationship between Chlamydia pneumoniae(Cpn)infection and the risk of lung cancer in Chinese Han people and to provide references for prevention of lung cancer.Methods A case-control study was conducted among 185 newly diagnosed lung cancer patients in three hospitals(the First Clinical Medical College of Fujian Medical University,the Affiliated Union Hospital of Fujian Medical University and Fuzhou General Hospital)and 190 non-cancer patients or physical examinees from the three hospitals during the same period as the controls betwecn July 2012 and January 2013.All the cases and controls had a face-to-face questionnaire survey and 5 ml blood sample collected for Cpn antibody IgG and IgA detection with Savyon^TM test.Results The positive rate the cases was 59.46%for IgG and 26.49%for IgA,which were all higher than those of the controls(34.21%and 6.84%)(P<0.05).After adjusting for sex,age,marital status,body mass index,education,and occupation,high titer of IgG(1:64-≥1:512)and IgA(1:32-1:64)increased the risk of lung cancer compared to the low titer of IgG(<1:64 and IgA<1:32),with the odds ratio(OR)of 2.44(95%confidence interval[95%CI]:1.56-3.81)and 3.79(95%CI:1.88-7.65),respectively.The Results also indicated that the IgG/IgA antibody and smoking,environment tobacco smoking(ETS),lung diseases and family history of lung cancer had synergistic effects on the incidence of lung cancer(P<0.05).Conclusion There is an association between Cpn infection and lung cancer.The IgG/IgA antibody and smoking,ETS,lung diseases and family history of lung cancer have synergistic effects on the incidence of lung cancer.