福建省HIV/AIDS病例配偶/固定性伴HIV感染情况分析

目的 分析福建省艾滋病病毒(HIV)/艾滋病(AIDS)病例配偶/固定性伴HIV感染情况和影响因素。方法 对2008年1月1日-2013年12月31日福建省新发现的HIV/AIDS病例进行回顾性调查,了解HIV/AIDS病例的配偶/固定性伴的HIV抗体阳转情况,应用单因素和多因素分析法探讨HIV/AIDS病例配偶/固定性伴HIV抗体阳转的影响因素。结果 共调查2008年1月1日-2013年12月31日福建省新发现的HIV/AIDS病例872例,其配偶/固定性伴出现HIV抗体阳转的比例为26.5%(231/872);36.6%(319/872)病例在末次随访时报告最近3个月内与配偶/固定性伴发生性行为,每次均使用安全套的比例为93.4%(298/319);配偶/固定性伴HIV抗体阳转在不同性别、文化程度、CD₄计数和安全套使用间差异均有统计学意义(均P<0.01);多因素logistic回归分析显示,先感染HIV的一方为男性(OR=0.338,95%CI=0.241~0.475,P<0.001)、大专及以上文化程度(OR=0.209,95%CI=0.067~0.654,P=0.007)、CD₄计数>350个/mm³(OR=0.521,95%CI=0.363~0.748,P<0.001)和发生性行为时每次均使用安全套(OR=0.054,95%CI=0.015~0.193,P<0.001)是配偶/固定性伴出现HIV抗体阳转的影响因素。结论 HIV/AIDS病例的配偶/固定性伴已经成为受HIV侵袭的重要人群,应进一步规范HIV抗体检测结果告知,阻断其在配偶/固定性伴间的传播。

HIV infection among couples and regular sexual partners of HIV/AIDS patients in Fujian province

Objective To analyze the prevalence and related factors of human immunodeficiency virus(HIV)infection among couples and regular sexual partners of HIV/acquired immunodeficiency syndrome(AIDS)cases in Fujian province.Methods HIV/AIDS patients first diagnosed between 1 January,2008 and 31 December,2013 were surveyed with a questionnaire and followed up retrospectively to examine HIV antibody positive conversion among their couples and regular sexual partners.Univariate and multivariate analysis were adopted in data analyse.Results Of the 872 patients surveyed,26.5%reported positive conversion of HIV antibody of their couples or regular sexual partners;36.6%reported sexual contact with their couples or regular sexual partners in the previous 3 months at the time of last follow-up.Of the patients reporting sexual contact with their couples or regular sexual partners,93.4% used condom every time during the sexual contacts.Significant differences in HIV antibody positive conversion rate of the couples and regular sexual partners were observed among the patients of different gender,educational background,CD₄ count,and condom use.Logistic regression analyses indicated that the factors related to HIV antibody positive conversion of the couples and regular sexual partners of the patients included a male being the HIV positive first(odds ratio[OR]=0.338,P<0.001),with the education of college or above(OR=0.209,P=0.007),with a CD₄ count greater than 350/mm³(OR=0.521,P<0.001),and using condom in every sexual contact(OR=0.054,P<0.001).Conclusion Couples and regular sexual partners of HIV/AIDS patients are key populations at risk of HIV infection.Notification procedure of HIV antibody detection should be standardized to control HIV transmission between HIV/AIDS patients and their couples and regular sexual partners.