| 摘 要： | ![]()
Objective To detect the changes of transforming growth factor beta 1 (TGF-*1) following implantation of bone matrix gelatin (BMG) and evaluate biological activits and antigen of BMG. Methods Twenty cases with disturbance of bone union were used as Group BMG and 20 cases with fresh fracture as control group. Internal fixation was done in both groups. TCF-β1 was detected 1 week before operation, 1 week and 2 weeks after operation respectively. Results (1) TCF-β1 in the Group BMG showed very significant difference postoperatively compared with preoperation ( P < 0. 01), and significant difference at the second postoperatie week compared with the first postoperative week (P<0.05). (2) There was insignificant difference in the control group precperatively and postoperatively (P>0.05). (3) In Group BMG,significant difference was found compared with control group preoperatively (P < 0. 05). Conclusion Implantation of BMG show remarkable activity of bone formation without immunoreaction. 5 refs,1 tab.
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