The expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface

Objective To study the expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface. Methods Tissue samples came from 25 cases of cavernous venous malformations, 12 cases of normal moderate veins and 12 cases of normal small veins. Envision immunohistochemical stain was used to investigate the expression of Ⅳ collagem,fibronectin,laminin, VEGF and Ang-1. The results were analyzed semi-quantitatively. Results The distribution of structural proteins in cavernous venous malformations is similar to moderate and small veins, but the expression in venous malformations is less obviously. VEGF expression in cavernous venous malformations and small veins is stronger obviously than moderate veins. Ang-1 expression in snail veins is stronger remarkably than cavernous venous malformations and moderate veins. Conclusion The abnormal expression of structural proteins may be an important factor in etiopathology and progress of cavernous venous malformations.