| 他克莫司和雷帕霉素对肝癌肝移植术后患者的疗效比较 |
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| 引用本文： | 陈建斌,陈国勇,孙建军,李彩丽.他克莫司和雷帕霉素对肝癌肝移植术后患者的疗效比较[J].中国医疗前沿,2011(20):57-58. |
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| 作者姓名： | 陈建斌 陈国勇 孙建军 李彩丽 |
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| 作者单位： | 河南省郑州人民医院肝脏外科中心; |
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| 摘 要： | 目的探讨免疫抑制剂他克莫司和雷帕霉素对肝癌肝移植术后受者治疗预后的比较。方法将22例肝癌肝移植术后患者随机分为两组：FK506组11例：术后采用FK506＋MMF＋Pred方案;Rapa组11例：术后4周内采用FK506＋MMF＋Pred方案,4周后改用Rapa＋MMF＋Pred方案。比较两组患者术后的肿瘤复发情况、死亡（因肿瘤因素）、排斥反应、感染发生率及肝、肾功能等情况。结果 FK506组患者与Rapa组患者在术后急性排斥反应、感染发生率、同时期的谷丙转氨酶（ALT）浓度方面差异无统计学意义（P〉0.05）;两组患者在术后肿瘤复发率、死亡率、血肌酐（CREA）浓度方面差异有统计学意义（P〈0.05）,Rapa组患者比FK506组患者术后疗效更好。结论雷帕霉素能明显改善肝癌肝移植术后患者的预后,并无肾功能损害,且不增加排斥反应的发生率,为肝癌肝移植术后的治疗提供了一种新的选择。
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| 关 键 词： | 他克莫司 雷帕霉素 肝移植 肿瘤复发 |
Comparison of the efficacy of FK506 and rapamycin application on liver cancer liver transplant patients after surgery |
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| CHEN Jian-bin,CHEN Guo-yong,SUN Jian-jun,et al..Comparison of the efficacy of FK506 and rapamycin application on liver cancer liver transplant patients after surgery[J].China Healthcare Innovation,2011(20):57-58. |
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| Authors: | CHEN Jian-bin CHEN Guo-yong SUN Jian-jun |
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| Institution: | CHEN Jian-bin,CHEN Guo-yong,SUN Jian-jun,et al.Liver Surgery Center,Zhengzhou People's Hospital,Zhengzhou 450053,China |
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| Abstract: | Objective To investigate the.Comparison of prognosis of Immunosuppressant FK506 and Rapamycin application on liver cancer Liver transplant patients after surgury.Methods The 22 patients of liver cancer Liver transplantation after surgury were random Divided into two groups.FK506 group 11 patients: FK506+MMF+Pred was applied.Rapa group 11 patients: FK506+MMF+Pred was applied in four weeks after surgury.Rapa+MMF+Pred was applied after four weeks.The situation of tumor recurrence,death(because of tumor factor)... |
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| Keywords: | FK506 Rapamycin Liver transplant Tumor recurrence |
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