| 白芍总苷联合甲氨蝶呤与来氟米特治疗类风湿关节炎疗效及安全性的研究 |
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| 引用本文： | 王妤,李军霞,李小峰. 白芍总苷联合甲氨蝶呤与来氟米特治疗类风湿关节炎疗效及安全性的研究[J]. 中国医疗前沿, 2011, 0(19): 16-17 |
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| 作者姓名： | 王妤 李军霞 李小峰 |
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| 作者单位： | 山西医科大学第二医院风湿免疫科; |
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| 摘 要： | 目的研究白芍总苷联合甲氨蝶呤与来氟米特治疗类风湿关节炎的临床疗效及安全性。方法将70例诊断明确的RA患者随机分为治疗组和对照组,完成本次实验的仅有64例。治疗组33例给予甲氨喋呤（MTX）＋来氟米特（LEF）＋白芍总苷（TGP）;对照组31例给予甲氨喋呤（MTX）＋来氟米特（LEF）。分别于治疗0、4、8、12周观察患者关节症状改善程度及药物副作用。结果治疗第12周后疗效比较：2组ACR20、50、70分别为90%Vs 74%、70%Vs 52%、45%Vs 35%,差异均有显著意义（P〈0.05）。治疗12周后,治疗组在关节肿胀、关节压痛、晨僵时间、血沉、DAS28评分等临床和实验室指标的改善均优于对照组,差异具有统计学意义（P〈0.05）;MTX＋LEF＋TGP组的肝损害低于MTX＋LEF组。结论联合应用TGP治疗活动期RA,能很好的缓解患者的关节症状;且不良反应发生率低,患者依从性高。
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| 关 键 词： | 类风湿关节炎 白芍总苷 疗效 安全性 |
Comparison of efficacy and safety of Total Glucosides of Paeony combined with methotrexate and leflunomind in the treatment of Rheumatoid Arthritis |
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| WANG YU,LI Jun-xia,LI Xiao-feng. Comparison of efficacy and safety of Total Glucosides of Paeony combined with methotrexate and leflunomind in the treatment of Rheumatoid Arthritis[J]. China Healthcare Innovation, 2011, 0(19): 16-17 |
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| Authors: | WANG YU LI Jun-xia LI Xiao-feng |
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| Affiliation: | WANG YU,LI Jun-xia,LI Xiao-feng.Department of Rheumatology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China |
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| Abstract: | Objective To investigate comparison of efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomind in the treatment of Rheumatoid Arthritis.Methods Total 70 patients were divided in to 2 groups randomly,Only 64 patients completed in this experiment.one is the MTX and LEF group,33cases and the other is the MTX and LEF and TGP group,31cases.We measured the improve degree of joint symptoms and drug side effect every 4 weeks for three months.Results We found that the effective p... |
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| Keywords: | Rheumatoid arthritis Total Glucosides of Paeony Efficacy Safety |
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