| 依达拉奉对肝脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 郑健,闫慧明,贾彬.依达拉奉对肝脏缺血再灌注损伤的保护作用[J].中国医疗前沿,2011(22):23-24. |
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| 作者姓名： | 郑健 闫慧明 贾彬 |
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| 作者单位： | 山西医科大学研究生学院;山西医科大学第二临床医学院普通外科; |
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| 摘 要： | 目的探讨依达拉奉在肝脏缺血再管注后损伤后对肝脏的保护作用。方法将54只健康SD大鼠随机分为3组：假手术组（A组）、缺血再灌注对照组（B组）、依达拉奉干预组（c组），每组18只。大鼠肝脏缺血再灌注模型为阻断肝门30min，分别测定再灌注后2h、4h、6h肝丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST），黄嘌呤氧化酶（XOD），超氧化物歧化酶（SOD）。结果与A组比较，C组各时间点均可见ALT、AST、XOD明显增高，SOD降低（P〈005），而与B组比较，在C组再灌注后2、4、6h，ALT、AST、XOD值明显降低，SOD升高（P〈0．05）。结论依达拉奉能够减弱大鼠肝脏缺血再灌注损伤。
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| 关 键 词： | 肝脏 缺血再灌注损伤 依达拉奉 |
The Positive Effect of Edaravone on Hepatic Ischemia Reperfusion Injury |
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| ZHENG Jian,YAN Hui-ming,JIA Bin.Graduate School,Shanxi Medical University,General surgery,Taiyuan China.The Positive Effect of Edaravone on Hepatic Ischemia Reperfusion Injury[J].China Healthcare Innovation,2011(22):23-24. |
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| Authors: | ZHENG Jian YAN Hui-ming JIA BinGraduate School Shanxi Medical University General surgery Taiyuan China |
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| Institution: | ZHENG Jian,YAN Hui-ming,JIA Bin.Graduate School,Shanxi Medical University,General surgery,Taiyuan 030001 China |
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| Abstract: | Objective Study of edaravone in hepatic ischemia-reperfusion injury on hepatic injection tube after the protective effect.Methods 54 healthy SD rats were randomly divided into 3 groups: sham operation group(group A),ischemia/reperfusion group(B group),the intervention of edaravone group(group C),18 rats in each group.Rat liver ischemia reperfusion model for occlusion of the hepatic portal 30min,were measured reperfusion after 2h,4h,6h of liver alanine transaminase(ALT),aspartate aminotransferase(AST),xanthi... |
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| Keywords: | Liver Reperfusion Injury Edaravone |
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