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| 替吉奥联合奥沙利铂治疗进展期胃癌的临床疗效研究 | |
| 引用本文： | 李毅星,王苗,尹先哲. 替吉奥联合奥沙利铂治疗进展期胃癌的临床疗效研究[J]. 中国医疗前沿, 2011, 0(21): 9-10,85 |
| 作者姓名： | 李毅星 王苗 尹先哲 |
| 作者单位： | 河南省南阳市第二人民医院; |
| 摘 要： | 目的观察替吉奥（S-1）胶囊联合奥沙利铂注射液（L-OHP）治疗进展期胃癌（AGC）的临床疗效及不良反应。方法对符合入组条件的59例进展期胃癌患者，分为治疗组及对照组，治疗组采用S01联合奥沙利铂方案治疗，对照组采用OFL（奥沙利铂联合亚叶酸钙和5-氟尿嘧啶）方案治疗。结果治疗组CR4例（13．3％），PR10例（33．3％），SD14例（46．7％），PD2例（67％），RR46．6％，DCR93．3％；对照组CR0例，PR6例（20．7％），SD15例（51．7％），PD8例（27．6％），RR207％，DCR72．4％。两组对比有效率和疾病控制率有统计学差异（P〈0．05）。治疗组不良反应发生率明显较对照组低（P〈0．05）。结论替吉奥胶囊联合奥沙利铂注射液方案治疗进展胃癌的疗效可靠、毒副作用较轻，不良反应可以耐受，是治疗晚期胃癌，特别是年龄较大、一般状态较差的患者的安全有效的治疗方案。 |
| 关 键 词： | 替吉奥 奥沙利铂 AGC 疗效 |
Clinical Efficacy Study of S-1 Capsule with Oxaliplatin in the Treatment of AGC |
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| LI Yi-xing,WANG Miao,Yin Xian-zhe. Clinical Efficacy Study of S-1 Capsule with Oxaliplatin in the Treatment of AGC[J]. China Healthcare Innovation, 2011, 0(21): 9-10,85 | |
| Authors: | LI Yi-xing WANG Miao Yin Xian-zhe |
| Affiliation: | LI Yi-xing,WANG Miao,Yin Xian-zhe.Department of Medical Oncology,Nanyang Second People's Hospital,Nanyang 473300,China |
| Abstract: | Objective To observe the efficacy and toxicity of S-1 capsule combined with oxaliplatin in the treatment of the advanced gastric cancer(AGC) patients.Methods All the 59 patients with AGC were divided two chemotherapy groups: the experimental group were treated with S-1 Capsule and Oxaliplatin and the control group with OFL plan.Results Of the experimental group patients,CR were observed in 4 patient,PR in 10 patients,SD in14 patients,and PD in 2 patients.The total response rate was 46.6%.The disease control... |
| Keywords: | S-1 Capsule Oxaliplatin AGC Efficacy |
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