| HPLC法测定兰索拉唑胶囊中兰索拉唑的含量 |
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| 引用本文： | 陈志,吴云.HPLC法测定兰索拉唑胶囊中兰索拉唑的含量[J].安徽医药,2013,17(6):954-955. |
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| 作者姓名： | 陈志 吴云 |
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| 作者单位： | 安庆医药高等专科学校,安徽,安庆,246052;安庆市立医院,安徽,安庆,246003 |
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| 摘 要： | 目的建立并优化测定兰索拉唑胶囊中兰索拉唑含量的高效液相色谱法。方法色谱柱为依利特C18(4.6 mm×250mm,5μm),流动相为乙腈-0.1 mol.L-1磷酸盐缓冲液(pH7.2)(75∶25),检测波长为285 nm。结果兰索拉唑在浓度为线性范围为8～160 mg.L-1,相关系数为0.999 9,平均加样回收率为100.1%,RSD=1.19%。结论该方法操作简单、快速、准确,可用于兰索拉唑胶囊中兰索拉唑的含量测定。
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| 关 键 词： | 兰索拉唑 含量测定 HPLC |
Determination of Lansoprazole in Lansoprazole capsules by HPLC |
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| CHEN Zhi,WU Yun.Determination of Lansoprazole in Lansoprazole capsules by HPLC[J].Anhui Medical and Pharmaceutical Journal,2013,17(6):954-955. |
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| Authors: | CHEN Zhi WU Yun |
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| Institution: | 1. Anqing Medical and Pharmaceutical College ,Anqing,Anhui 246052, China ;2. Anqing Municipal Hospital, Anqing ,Anhui 246003, China) |
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| Abstract: | Objective To establish an HPLC method for the determination of Lansoprazole in Lansoprazole capsules. Methods The sepa- ration was performed at 30℃ on an Elite C18 （4.6 mm× 250 mm,5μm）column eluted with the mobile phase consisting of acetonitrile-0.1 mol · L-I phosphate buffer（ pHT. 2,75： 25 ）. The detection wavelength was 285 rim. Results The calibration curve of Lansoprazole was linear within the range of 8 - 160 mg·h -1（ r =0.999 9）. The average recovery was 100.1%. The RSD of precision was 1, 19%. Conclu- sion The method is simple,reproducible,which can be used to determine the content of lansoprazole capsules. |
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| Keywords: | Lansoprazole content determination HPLC |
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