粒细胞肉瘤十例临床特点分析

 目的　探讨粒细胞肉瘤（GS）的临床表现、病理诊断、治疗方法及预后。方法　回顾性分析10例GS患者的临床资料。结果　10例确诊为GS的患者中，5例为原发性GS，1例为急性早幼粒细胞白血病，3例为慢性髓细胞白血病，1例为骨髓增生异常综合征。所有患者采用手术、化疗或者伊马替尼治疗。1例失访；2例生存，其中1例使用含大剂量阿糖胞苷化疗方案的患者生存66个月；7例死亡，死亡患者的生存期为4～17个月。结论　GS临床罕见，细胞形态学检查及免疫组织化学检查对其准确诊断非常必要。GS临床预后差，急性髓细胞白血病样化疗方案为该病的主要治疗方法，高强度的化疗及造血干细胞移植治疗可以延长患者生存期。

Analysis on clinical of 10 patients with granulocytic sarcoma

Objective　To explore the clinical characteristics,diagnosis,therapy and prognostic features of granulocytic sarcoma (GS). Methods　Retrospective analysis was used to analyse 10 cases who were diagnosed with GS. Results　Five patients were diagnosed with primary GS. GS was accompanied by APL in one case, CML in 3 cases and MDS in one case. Patients were treated with resection and chemotherapy, or imatinib treatment. Follow-up data were available from 9 patients, with 2 patients being still alive. The survival of one patient who received high-dose cytarabine chemotherapy was 66 months. The other 7 patients died of tumor-related diseases, and their survival ranged from 4 to 17 months. Conclusion　GS is a rarely diagnosed disease. A correct diagnosis of GS depends on detailed morphological examination and immunohistochemical study. The clinical outcome of patients is poor, and AML-type chemotherapy is the proper treatment for GS.High-intensity chemotherapy and hematopoietic stem cell transplantation might improve long-term survival.