| 恶性疟原虫对青蒿酯钠抗性的体外培育 |
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| 引用本文： | 江钢锋.恶性疟原虫对青蒿酯钠抗性的体外培育[J].中国寄生虫学与寄生虫病杂志,1992,10(1):37-39. |
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| 作者姓名： | 江钢锋 |
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| 作者单位： | 广东医药学院寄生虫学教研室 广州 |
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| 基金项目： | 卫生部青年科学研究基金 |
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| 摘 要： | 恶性疟原虫FCR_3在体外采用剂量递增间隔接触方法在青篙酯钠的作用下产生了对该药的抗药性。在接触药物前,青蒿酯钠对该虫株裂殖体成熟抑制的半数抑制浓度(IC_(50))为1.6ng/ml(4.1nmol/L),经过130d间隔接触药物后,虫株对青蒿酯钠的敏感性下降,其IC_(50)值增高至约为亲代系的3倍,即4.7ng/ml(12.2nmol/L)。抗性系在去除药物作用后,其抗性水平很快下降。
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| 关 键 词： | 恶性疟原虫 抗疟药 青蒿酯钠 抗药性 |
IN VITRO DEVELOPMENT OF SODIUM ARTESUNATE RESISTANCE IN PLASMODIUM FALCIPARVM |
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| Jiang Gang-Feng.IN VITRO DEVELOPMENT OF SODIUM ARTESUNATE RESISTANCE IN PLASMODIUM FALCIPARVM[J].Chinese Journal of Parasitology and Parasitic Diseases,1992,10(1):37-39. |
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| Authors: | Jiang Gang-Feng |
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| Institution: | Department of Parasitology, Guangdong Medical and Pharmaceutical College. |
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| Abstract: | Plasmodium falciparum(Lab.culture FCR3 isolate) developed resistance to sodium artesunate after exposure to the drug in vitro.The drug effective concentration which resulted in 50 per cent schizont maturation inhibition (IC50) was 1.6ng/ml (4.1nmol/L) before exposure to the drug.After 130 days of discontiguous exposure to sodium artesunate in a stepwise fashion,the sensitivity of the isolate to the drug decreased,with its IC50 3-fold higher than that of the parent isolate.The resistance to artesunate decreased significantly after the resistant line was grown in drug-free medium. |
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| Keywords: | Plasmodium falciparum antimalarials artesunate drug resistance |
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