首页 | 本学科首页   官方微博 | 高级检索  
     

肠道菌群在阿尔茨海默病发病中的作用
引用本文:刘诺王真真陈乃宏. 肠道菌群在阿尔茨海默病发病中的作用[J]. 神经药理学报, 2017, 7(5): 28-33. DOI: 10.3969/j.issn.2095-1396.2017.05.005
作者姓名:刘诺王真真陈乃宏
作者单位:中国医学科学院药物研究所& 神经科学中心,北京,100050,中国
基金项目:国家自然科学基金项目(No.81603315,No.81730096,No.U1402221);中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-004);神经变性病教育部重点实验室开放研究课题(No.2016SJBX03);国家重点实验室开放课题(No.GTZK201610);中国博士后科学基金(No.2013M540066).
摘    要:随着人口老龄化程度的加重,阿尔茨海默病(Alzheimer’s disease,AD)的发病率不断上升,然而目前该病的对因治理仍未取得突破。近年来,肠道菌群在AD 发病进程中发挥的作用日益受到关注,肠道菌群的种类和比例随着年龄增加会发生变化,其代谢产物数量改变对认知行为有一定影响,肠道菌群还与脑肠轴双向交流、相互作用。目前,已经证实肠道细菌参与到包括Aβ蛋白沉积、tau 蛋白过度磷酸化、神经炎症、氧化应激损伤、血脑屏障通透性增加、神经递质失平衡、胰岛素抵抗在内的AD 发病机制中。未来,针对致病相关种类的肠道细菌进行特异性调节将是重要的研究方向。

关 键 词:肠道菌群  阿尔茨海默病  发病机制  

The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease
LIU Nuo,WANG Zhen-zhen,CHEN Nai-hong. The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease[J]. Journal of Hebei North University(Medical Edition), 2017, 7(5): 28-33. DOI: 10.3969/j.issn.2095-1396.2017.05.005
Authors:LIU Nuo  WANG Zhen-zhen  CHEN Nai-hong
Affiliation:Institute of Material Medica & Neuroscience Center,Chinese Academy of Medical Sciences,Beijing,100050,China
Abstract:Along with aggravation of aging of population,the incidence of Alzheimer’s disease is getting higher and higher. However,etiological treatment of this disease is still unsatisfying. In recent years,the role of gut flora in the pathogenesis of AD has received more and more attention. Types and ratios of gut flora change along with the growth of the age,and the variety of quantities of metabolites makes a difference in the cognitive behavior. Besides,gut flora interacts with gut-brain axis. Nowadays,we have confirmed the role of gut flora in mechanisms of the pathogenesis of AD,including amyloidosis,hyperphosphorylation of tau protein,neuro-inflammation,oxidative stress damage,increase of the permeability of the bloodbrain barrier neurotransmitter imbalance and insulin resistance. In the future,specific regulation of pathogenesis-related gut bacteria will be an important research area.
Keywords:gut flora  Alzheimer’s disease  mechanisms of pathogenesis  
本文献已被 维普 等数据库收录!
点击此处可从《神经药理学报》浏览原始摘要信息
点击此处可从《神经药理学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号