110例≥50岁老年AIDS病人的生存时间及影响因素分析

目的了解大冶市≥50岁艾滋病（AIDS）病人的生存时间及影响因素,为相关部门制订及落实AIDS病人的治疗、救助等政策提供科学依据。方法利用国家艾滋病综合防治信息系统中的数据,使用SPSS 15.00软件进行分析。结果 110例AIDS病人的平均观察时间为（15.91±3.86）个月;总死亡率为22.29/1000人月,AIDS相关死亡率为18.29/1000人月;截止观察终点,9年生存率为49.00%,平均生存时间44.86个月。单因素分析显示,性别和治疗情况是AIDS病人平均生存时间的影响因素（P〈0.05）,多因素COX回归模型表明,男性死亡风险高于女性HR=4.723,95%可信区间（CT）：1.415~15.763];高效抗反转录病毒治疗（HAART）能降低AIDS死亡风险（HR=0.066,95%CI：0.029--0.148）。结论≥50岁老年AIDS病人死亡风险较一般AIDS病人高,HAART是延长AIDS病人生存时间的有效手段之一,应进一步扩大HAART覆盖面,尽早进行治疗。

An analysis of survival time and related factors of 110 HIV/AIDS patients aged 50 years or above

Objective To understand the survival time and related factor of HIV/AIDS patients aged 50 years or above in Daye city and to provide scientific evidence for the relevant departments to formulate and implement policies about HIV/AIDS treatment and supports. Methods The data were collected from the comprehensive national AIDS prevention and control information system, and analyzed using SPSS15.00 software. Results For the 110 cases, the average observation time was 15.91 ±3.86 months. The total mortality was 22.29/1000person-month and AIDS related mortality was 18.29/1000 person-month. The average survival time was 44.86months with a 9-year survival rate of 49.00% by the end of the observation. Univariate analysis showed that gender and treatment were influen- cing factors of average survival time （P（O. 05）. Multivariate Cox regression showed that the male had a higher risk of death than the female （HR=4. 723,CI=1. 415--15. 763）. HAART reduced substantially the risk of death （HR =0. 066, CI=0. 029--0. 148）. Conclusions The risk of death of patients aged 50 years or above is higher than that of general HIV/AIDS patients. HAART is an effective approach to prolong survival of AIDS patients and should be more available and earlier to start.