Measurement of platelet antibodies: where do we stand? |
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Authors: | J Winiarski |
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Institution: | Department of Paediatrics, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden |
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Abstract: | The immune pathogenesis of idiopathic thrombocytopenic purpura (ITP) is well established; however, the diagnostic criteria do not require identification of platelet autoantibodies. The abundance of methods devised for the measurement of platelet antibodies over the years provides evidence of the so-far futile search for a reliable diagnostic assay. The latest generation of platelet antigen-specific assays has widened the knowledge of autoimmune mechanisms in thrombocytopenia, but they still lack sufficient sensitivity to be a useful tool in the routine evaluation of thrombocytopenic patients. |
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Keywords: | Antibodies idiopathic immune platelets thrombocytopenia |
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