新生儿HIE脐血IL-6、IL-8与TNF-α变化及临床意义探讨

为探讨新生儿缺氧缺血性脑病 ( HIE)脐血 IL - 6、IL - 8与 TNF-α的变化及临床意义 ,应用放射免疫法检测了 4 0例 HIE患儿 IL- 6、IL- 8与 TNF- α水平 ,并与 4 0例正常新生儿比较。结果显示与正常新生儿比较 ,HIE患儿与正常对照儿相比脐血IL - 6水平分别为 ( 61.0 4± 2 3 .0 6)对 ( 91.83± 3 7.5 4 ) ng/L ( P<0 .0 1) ,IL - 8分别为( 0 .3 4± 0 .0 9)对 ( 0 .2 6± 0 .0 7) μg/L( P<0 .0 1) ,TNF- α分别为 ( 1.0 3± 0 .3 0 )对 ( 0 .83± 0 .3 1) μg/L( P<0 .0 1) ;而且病情越重改变越明显。因此 ,我们认为 ,围产期窒息与HIE患儿脐血 IL - 6水平减低、IL - 8与 TNF-α水平升高有关 ;它们可能参与了新生儿缺氧缺血性脑损伤的某些发病过程

Cord blood levels of interleukin-6 and interleukin-8 and tumor necrosis factor-alpha in HIE of neonates and its clinical significance

To assess the influence of birth asphyxia and HIE on interleukin 6(IL 6), interleukin 8 (IL 8) and tumor necrosis factor alpha (TNF α) cord blood levels in asphyxiated neonates and to analyze the clinical significance,by using cord blood samples whick were obtained at time of delivery from 80 full term neonates for measuring serum levels of IL 6, IL 8 and TNF a by using radioimmunoassays, The neonates were classified into two groups according to the presence or absence of birth asphyxia. HIE results shoused birth asphyxia was associated with a decrease in IL 6 (61.04±23.06 vs 91.83±37.54 ng/L, P<0.01) and an increase in IL 8 (0.34±0.09 vs 0.26±0.07 μg/L,P<0.01) and TNF α (1.03±0.30 vs 0.83±0.31 μg/L, P<0.01). Birth asphyxia and HIE were associated with elevated IL 8 and TNF a cord blood levels in full term neonates while with asphyxia was associated with decreased IL 6 levels.