血清CEA、CA125、CA19-9检测在大肠癌诊治中的价值

目的探讨血清CEA、CA125、CA19-9检测在大肠癌诊断和治疗中的价值。方法以某院2005-01／2007-05月收治并手术的102例大肠癌病人为研究对象，同时选取40例正常人做为对照组，用微粒子免疫荧光法测定两组血清CEA、CA125、CA19-9的含量。结果三项指标定量检测大肠癌组明显高于对照组，其阳性率与部位、大体类型、组织类型无明显相关。三项指标阳性率DukesC＋D期明显高于DukesA＋B期；CEA、CA125、CA19-9三项指标敏感度分别为34．3％、35．2％、37．2％，特异度均为95．0％；三项联检敏感度为58．9％；特异度为92．5％。而在DukesC＋D期，三项联检敏感度为89．1％，特异度为92．5％。结论血清CEA、CA125、CA19-9三项联检在DukesC、D期大肠癌病人诊断价值较高，有助于判断大肠癌病理分期并指导手术范围。

Diagnostic and Therapeutic Value of Serum CEA,CA125 and CA19-9 in Colorectal Carcinoma

Objective To evaluate the diagnostic and therapeutic value of serum CEA,CA125 and CA19-9 in colorectal carcinoma. Methods One hundred and two patients with colorectal carcinoma treated surgically in our hospital between January 2005 and May 2007 and 40 healthy adults as control were studied. The level of serum CEA, CA125 and CA19-9 were detected by microparticle enzyme immunoassay. Results The positive rates of serum CEA, CA125 and CA19-9 were not associated with location, gross morphology and histological type. The positive rates of three markers were higher in Dukes C＋ D than in Dukes A＋ B. The sensitivities of CEA,CA125 and CA19-9 were 34. 3%,35. 2% and 37. 2% respectively. The specificities were 95. 0%. The combination of CEA, CA125 and CA19-9 had a sensitivity of 58. 9% and a specificity of 92. 5 %. In Dukes C ＋ D the sensitivity was 89. 1% and the specificity was 92. 5 %. Concision The combination of CA125, CA1929 and CEA is important in diagnosis of colorectal carcinoma in Dukes C ＋ D, and may help to determine the stage and operation radius of colorectal cancer.