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Evaluation of normal and neoplastic human tissue for BK virus |
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| Authors: | Mark A. Israel Malcolm A. Martin Kenneth K. Takemoto Peter M. Howley Stuart A. Naronson Diane Solomon George Khoury |
| Affiliation: | 1. Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, USA;2. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, USA;3. Laboratory of Pathology, National Cancer Institute, USA;4. Laboratory of RNA Tumor Viruses, National Cancer Institute, USA;5. Laboratory of DNA Tumor Viruses, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA |
| Abstract: | Despite an extensive search using sensitive DNA hybridization techniques, we were unable to demonstrate the presence of BK Virus DNA sequences in human neoplastic tissues. Evaluation of numerous human tumor cell lines for BK Virus T-antigen and sera from patients with known malignancies for anti-BK Virus T-antibody was also negative. |
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