大肠肿瘤p53基因表达及其临床病理意义

应用免疫组织化学Ｓ－Ｐ法检测了１０６例良，恶性大肠组织中抑癌基因ｐ５３基因表达民政部结果发现；正常大肠粘膜及非肿瘤性息肉均阴性；腺癌中１８．１８％ｐ５３阳性，但均为弱阳性，局灶型，而腺癌组织中４２．１１ｐ５３阳性，其中７５％为强阳性或阳性；癌组织中ｐ５３阳性表达与大肠癌的分化、组织学类型、侵范围是淋巴结转移等因素有关，低分化腺癌及粘液癌阳性率较高，ｐ５３阳性及强阳性者更易于侵出肌层及发生淋巴结转移

p53 expression in colorectal tumors

p53 protein expression was studied immunohistochemically in a series of 106 benign and malignant colorectal tumors. Using monocolonal antibody DO-7, p53 protein was identified in 18. 18 per cent of adenomas and 42. 11 per cent of adenocarcinomas, whereas all the normal large bowel mucosas and non-neoplastic polyps were negative. Yet the p53 expression was related to differentiation, histology and progression of the tumors. Poorly differentiated carcinomas and mucous carcinomas had higher incidence of p53 detection, and the carcinomas with marked positive p53 expression were more likely to penetrate the bowel wall and metastasize to lymph nodes.It is suggested that p53 mutation or over-expression are common in colorectal cancers, and marked p53 expression appears to relate to tumor progression.