| 注射用盐酸兰地洛尔与4种溶液的配伍稳定性考察 |
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| 引用本文： | 武媚然,姜亮萍,邵珠民,姬怀雪,孟庆华. 注射用盐酸兰地洛尔与4种溶液的配伍稳定性考察[J]. 临床合理用药杂志, 2014, 7(2): 29-30 |
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| 作者姓名： | 武媚然 姜亮萍 邵珠民 姬怀雪 孟庆华 |
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| 作者单位： | 武媚然(江苏师范大学化学化工学院,江苏省徐州市,211116)；姜亮萍(江苏师范大学化学化工学院,江苏省徐州市,211116)； 邵珠民 (徐州医学院附属医院,江苏省徐州市,221002)； 姬怀雪 (徐州医学院附属医院,江苏省徐州市,221002)； 孟庆华(江苏师范大学化学化工学院,江苏省徐州市,211116)； |
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| 摘 要： | 目的 研究盐酸兰地洛尔粉针剂与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液以及葡萄糖氯化钠注射液配伍后的稳定性.方法 采用高效液相色谱法（HPLC）测定注射用盐酸兰地洛尔与4种常用输液于室温（25℃）配伍4h内的含量,并测定不溶性微粒及pH值变化.结果 注射用盐酸兰地洛尔与上述4种输液配伍放置4h后,pH值、不溶性微粒、含量均无明显改变.结论 注射用盐酸兰地洛尔在上述4种输液中4h内稳定性良好.
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| 关 键 词： | 盐酸兰地洛尔 输液 配伍 稳定性 高效液相色谱法 |
The compatible stability of landiolol hydrochloride injection in four infusions |
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| Affiliation: | WU Mei-ran ＊ , JIANG Liang-ping, SHAO Zhu-min, et al. ＊ School of Chemistry and Chemical Engineering, Jangsu Normal University ,Xuzhou, Jiangsu 211116, China |
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| Abstract: | Objective To study the compatible stability of landiolol hydrochloride For Injection in 0.9% sodium chloride injection,5% glucose injection, 10% glucose injection and glucose and sodium chloride injection. Methods The content of landiolol hydrochloride during 4h was determined by high-pressure liquid chromatography（HPLC） when mixed with 4 kinds of infusions at room temperature（25℃ ）. The particulate matter and pH value was measured. Results After landiolol hydrochloride for injection was mixed with each of the four kinds Of infusions, the contents , the number of particles and pH val- ue had no obvious change in 4h. Conclusion Landiolol hydrochloride for injection has good compatible stability in the 4 kinds of infusions. |
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| Keywords: | Landiolol hydrochloride Infusions Compatibility Stability HPLC |
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