Alternative Manufacturing Concepts for Solid Oral Dosage Forms From Drug Nanosuspensions Using Fluid Dispensing and Forced Drying Technology |
| |
Authors: | Bastian Bonhoeffer Arno Kwade Michael Juhnke |
| |
Institution: | 1. Novartis Pharma AG, Technical R&D, P.O. Box, CH-4002, Basel, Switzerland;2. Institute for Particle Technology, TU Braunschweig, 38106 Braunschweig, Germany |
| |
Abstract: | Flexible manufacturing technologies for solid oral dosage forms with a continuous adjustability of the manufactured dose strength are of interest for applications in personalized medicine. This study explored the feasibility of using microvalve technology for the manufacturing of different solid oral dosage form concepts. Hard gelatin capsules filled with excipients, placebo tablets, and polymer films, placed in hard gelatin capsules after drying, were considered as substrates. For each concept, a basic understanding of relevant formulation parameters and their impact on dissolution behavior has been established. Suitable matrix formers, present either on the substrate or directly in the drug nanosuspension, proved to be essential to prevent nanoparticle agglomeration of the drug nanoparticles and to ensure a fast dissolution behavior. Furthermore, convection and radiation drying methods were investigated for the fast drying of drug nanosuspensions dispensed onto polymer films, which were then placed in hard gelatin capsules. Changes in morphology and in drug and matrix former distribution were observed for increasing drying intensity. However, even fast drying times below 1 min could be realized, while maintaining the nanoparticulate drug structure and a good dissolution behavior. |
| |
Keywords: | solid dosage form oral drug delivery individualized drug therapy formulation suspension nanotechnology excipients dissolution processing drying |
本文献已被 ScienceDirect 等数据库收录! |
|