A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis |
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| Authors: | Despoina Alataki A. Triantafyllidis José Gaal C. Rodiou J. Vouros A. Papathanasiou A. Papanicolaou V. Rombis Ronald R. de Krijger |
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| Affiliation: | (1) Department of Pathology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece;(2) Department of Urology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece;(3) Department of Pathology, Josephine Nefkens Institute, Erasmus MC-University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands; |
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| Abstract: | Background Catecholamine-producing tumours are called pheochromocytomas when they are located in the adrenal gland and sympathetic paragangliomas when they are located elsewhere in the abdomen. Rarely these tumours do not produce catecholamines and even more rarely they arise in the spermatic cord. Over the past decade, systematic mutation analysis of apparently sporadic cases of pheochromocytomas and paragangliomas has elucidated the frequent presence of germ line mutations in one of five candidate genes, including RET, VHL, SDHB, SDHC, and SDHD. |
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