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| 甘草黄酮抗实验性心律失常的作用 | |
| 引用本文： | 谢世荣 杨静娴. 甘草黄酮抗实验性心律失常的作用[J]. 基础医学与临床, 1998, 18(2): 72-74 |
| 作者姓名： | 谢世荣 杨静娴 |
| 作者单位： | 大连大学医学院药理教研室，大连医科大学药理教研室 |
| 摘 要： | 甘草黄酮（ｇｌｙｃｙｒｒｈｅｉｃｂｒｓｓ．ＧＢ）２ｍｇ／ｋｇ能明显对抗乌头碱２０μｇ／ｋｇ，ＢａＣｌ２２ｍｇ／ｋｇ和结扎左冠状动脉前降支诱发大鼠的室性心律失常。甘草黄酮也能明显对抗ＣａＣｌ２－Ａｃｈ（ＣａＣｌ２０．６％＋Ａｃｈ０．００２５％）混合液诱发小鼠心房纤颤或扑动，ＧＢ对大鼠心电图实验，证明了有负性频率作用，负性传导作用，这些作用可能是ＧＢ抗心律失常作用的药理基础。 |
| 关 键 词： | 甘草黄酮 奎尼丁 乌头碱 氯化钡 抗心律失常 |
Antiarrhythmic Effect of Glycyrrhetic Brass |
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| Xie Shirong Huang Caiyun Yang Jingxian Huang Shengying. Antiarrhythmic Effect of Glycyrrhetic Brass[J]. Basic Medical Sciences and Clinics, 1998, 18(2): 72-74 | |
| Authors: | Xie Shirong Huang Caiyun Yang Jingxian Huang Shengying |
| Abstract: | Glycyrrhetic Brass ( GB ) 2mg/kg could inhibit markedly the ventricular arrhythmias in- duced by aconitine 20 g/kg and BaCl_2 2mg/kg and coronary ligation in rat. lt also obviously reduced the incidence of atrium fibrillation produced by CaCl2-Ach (CaCl_2 0. 6 %+0. 0025 %) 10ml/kg in mice. These actions were similar to Quinidine. The ECG of rats was significantly P-R changed after i. v of GB 2mg/kg. Hearts were reduced ,the P-R and Q-T intervals were prologed . |
| Keywords: | Glycyrrhetic Brass (GB) Quinidine Aconitine BaCl2 orrhythmias |
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