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3. Chromosomal instability in B-lymphoblasotoid cell lines from Werner's and Bloom's syndrome patients |
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| Authors: | Masamitsu Honma Satoshi Tadokoro Hiroko Sakamoto Hedeyuki Tanabe Misako Sato Masanobu Sugimoto Yasuhiro Furuichi Takutomo Sato Toshio Sofuni Makoto Goto Makoto Hayashi |
| Affiliation: | 1. Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. 2. AGENE Research Institute, 200 Kajiwara, Kamakura. Kanagawa 247-0063, Japan. 3. Olympus Chromosome Research Center. 2-3 Kuboyama-cho, Hachioji-shi, |
| Abstract: | Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal recessive diseases in which the feature of premature aging and the elevated risk of neoplasia may be associated with genomic instability. To cha-racterize the genomic instability of WS and BS, B-lymphoblastoid cell lines (LCLs) from WS and BS patients were cytogenetically analyzed, comparing to those from healthy donors. Although all |
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