Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats |
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| Authors: | Hennenberg Martin Biecker Erwin Trebicka Jonel Jochem Kerstin Zhou Qi Schmidt Martina Jakobs Karl H Sauerbruch Tilman Heller Jörg |
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| Affiliation: | Department of Internal Medicine I, University of Bonn, Bonn, Germany. |
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| Abstract: | ![]()
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| Keywords: | BDL, bile duct ligation EC50, concentration producing a half-maximum effect GST, glutathione S-transferase GTP, guanosine triphosphate IP3, 1,4,5-triphosphate L-NAME, NG-nitro-L-arginine methyl ester MAP, mean arterial pressure MLC, myosin light chain MLC-P, phospho-MLC NO, nitric oxide NOS, nitric oxide synthase pEC50, negative logarithm of EC50 PLC, phospholipase C P-moesin, moesin phosphorylated at Thr-558 SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis SVR, systemic vascular resistance Y-27632, (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide |
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