依达拉奉对肝脏缺血再灌注损伤保护作用的临床研究

目的观察依达拉奉对肝切除术患者肝缺血再灌注损伤的保护作用。方法82例肝切除患者，随机分为对照组（n=40）和试验组（n=42），试验组给予依达拉奉。分别于术前及术后测定中性粒细胞（PMN）计数、血清谷丙转氨酶（ALT）、谷草转氨酶（AST）含量及肝组织中丙二醛（MDA）及超氧化物岐化酶（SOD）活件。结果肝脏缺血再灌注损伤后，对照组的ALT、AST水平及MDA含量明显高于试验组（P〈0．01或P〈0．05），SOD活性及PMN计数明显下降（P〈0．05）。结论依达拉奉对肝脏的缺血再灌注损伤有显著的保护作用，其机制可能与减少PMN在肝脏内的聚集进而调节肝组织氧化与抗氧化平衡有关。

Study of the protective effects of Edaravone against ischemia - reperfusion injury of the liver

Objective To investigate the protective effects and the mechanism of the preconditioning with edaravone against hepatic ischemia - reperfusion injury. Methods 82 patients who underwent liver resection were randomly divided into two groups, wich treatment group （ n = 42 ） reciving edaravone, and control group （ n = 40） without edaravone. The blood samples were taken before and ＇after surgery to determine the levels of PMN count and ALT,AST. The MDA and SOD concentrations were determine at liver tissue. Results After ischemia - reperfusion, the levels of ALT, AST, MDA in control group was significantly higher than those in treatment group （ P 〈 0. 01 or P 〈 0. 05 ）, but the activity of SOD and PMN count was decreased （ P 〈 0. 05 ）. Conclusion Preconditioning with edaravone can protect liver from ischemia reperfusion injury and the possible mechanism was the inhibition of PMN accumulation in the liver, and thereby adjust the oxidation/anti- oxidation in liver tissue.