青鹏软膏治疗慢性湿疹的疗效观察

目的 探讨外用青鹏软膏治疗慢性湿疹的有效性和安全性。方法 选择慢性湿疹患者95例，以随机数字表法将患者分为外用青鹏软膏组（33例）、0.2%氢化可的松乳膏组（32例）、10%尿素软膏组（30例），3组均每日用药2次，疗程为4周，定期复诊，记录患者的治疗效果及不良反应。结果 青鹏软膏、氢化可的松乳膏、尿素软膏组治疗慢性湿疹总有效率分别为78.8%、84.4%、46.7%。青鹏软膏组与氢化可的松乳膏组疗效比较，差异无统计学意义（P > 0.05）；青鹏软膏组与尿素软膏组疗效比较，差异有统计学意义（P < 0.05）。青鹏软膏组2例出现局部皮肤发红、伴灼热感，氢化可的松乳膏组1例出现局部刺痛感，患者均可耐受，不影响治疗，无严重不良事件发生。结论 外用青鹏软膏治疗慢性湿疹安全有效。

Clinical efficacy of Qingpeng ointment for the treatment of chronic eczema

Objective To evaluate the efficacy and safety of Qingpeng ointment in the treatment of chronic eczema.Methods Totally,95 patients with chronic eczema were enrolled and divided into 3 groups to receive topical Qingpeng ointment (n =33),0.2％ hydrocortisone cream (n =32),10％ urea ointment (n =30) respectively twice a day for 4 weeks.All the patients were followed up once a week for the evaluation of therapeutic and side effects.Results After 4-week treatment,the response rate was 78.8％,84.4％ and 46.7％ in the Qingpeng ointment-,hydrocortisone cream- and urea ointment-treated patients respectively.Significant differences were observed in the response rate between the Qingpeng ointment- and urea ointment-treated patients (P ＜ 0.05 ),but not between the hydrocortisone cream- and Qingpeng ointment-treated patients (P ＞0.05).Skin flushing with a sensation of burning was observed at the application sites of 2 patients treated with Qingpeng ointment,and tingling sensation at the application sites was reported in 1 patient treated with hydrocortisone cream.All of these adverse reactions were tolerable and had no influence on the treatment.Conclusion Topical Qingpeng ointment is effective and safe for the treatment of chronic eczema.