Mild Cognitive Impairment: Incidence and Risk Factors: Results of the Leipzig Longitudinal Study of the Aged |
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| Authors: | Tobias Luck Dr rer med Melanie Luppa Dr rer med Susanne Briel Dipl‐Psych Herbert Matschinger Dr phil Hans‐Helmut König Prof Dr med Stefan Bleich Prof Dr med Arno Villringer Prof Dr med Matthias C. Angermeyer Prof Dr med Steffi G. Riedel‐Heller Prof Dr med |
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| Affiliation: | 1. From the?Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany;2. ?Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment, (LIFE Center), University of Leipzig, Leipzig, Germany;3. #Max Planck Institute for Human Cognitive and Brain Sciences and Day Clinic of Cognitive Neurology University of Leipzig, Leipzig, Germany;4. *Department of Social Medicine, University of Leipzig, Leipzig, Germany;5. §Department of Medical Sociology and Health Economics, University Medical Center Hamburg‐Eppendorf, Hamburg, Germany;6. ∥Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany;7. **Center for Public Mental Health, G?sing a. W., Austria;8. and ??Department of Public Health, University of Cagliari, Cagliari, Italy. |
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| Abstract: | OBECTIVES: To provide information on age‐ and sex‐specific incidence rates of mild cognitive impairment (MCI) and risk factors for incident MCI. DESIGN: Prospective longitudinal cohort. SETTING: Leipzig Longitudinal Study of the Aged, a population‐based German study of the epidemiology of dementia and mild cognitive impairment. PARTICIPANTS: At baseline, 1,692 subjects aged 75 and older were included in the sample. MEASUREMENTS: Trained psychologists and physicians conducted structured clinical interviews including neuropsychological assessment and questions about sociodemographics, familial history of dementia, activities of daily living, subjective memory impairment, and lifestyle (alcohol consumption, smoking) at participants' homes. Structured third‐party interviews were conducted with proxies. Incidence was calculated according to the person‐years‐at‐risk method. Cox proportional hazards models were used to examine the association between risk factors and incident MCI. RESULTS: During an 8‐year follow‐up period, 26.4% (n=137) of the 519 study participants (population at risk) were identified as incident MCI cases (person‐years=1,791.1). The overall incidence rate of MCI was 76.5 (95% confidence interval=64.7–90.4) per 1,000 person‐years. Older age, subjective memory impairment, impairment in instrumental activities of daily living, and antecedent lower cognitive performance were found to be significantly associated with the development of future MCI. CONCLUSION: MCI is highly incident in the elderly population. For the purpose of early detection of dementia, subjective memory impairment should be taken seriously as a possible prestage of MCI. |
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| Keywords: | mild cognitive impairment risk factors incidence epidemiology dementia |
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