Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
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| Authors: | Yunjung Choi Hyunju Kim Moonseok Choi Eun-Jeong Yang Toru Takumi Hye-Sun Kim |
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| Affiliation: | 1. Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea;2. Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea;3. RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan;4. Seoul National University Bundang Hospital, Seongnam, 463-707, South Korea;5. Neuroscience Research Institute, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea |
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| Abstract: | ![]()
The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp/+ mice). In patDp/+ mice-derived FNSCs, multipotency was maintained for a longer period, the population of neurons was downregulated, and that of astrocytes was upregulated significantly after differentiation induction. These results suggest that the dysregulation of FNSCs differentiation could affect cortical development and behavioral deficits in the early postnatal stage shown in the patDp/+ mice. |
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| Keywords: | Autism spectrum disorder Paternal 15q11-13 duplication FNSCs differentiation |
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