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Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy
Authors:Abdullah Al Emran  Aniruddha Chatterjee  Euan J. Rodger  Jessamy C. Tiffen  Stuart J. Gallagher  Michael R. Eccles  Peter Hersey
Affiliation:1. Melanoma Immunology and Oncology Group, The Centenary Institute, University of Sydney, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia;2. Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New Zealand;3. Maurice Wilkins Centre for Molecular Biodiscovery, Level, 3A Symonds Street, Auckland, New Zealand;4. These authors contributed equally;5. Senior author
Abstract:
Keywords:DNA methylation  epigenetic remodeling  viral mimicry  immune checkpoint blockade  PD1  PD-L1  melanoma  resistance  biomarker  T cell exhaustion
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