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Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort
Authors:Milica G. Kramberger  Katarina Giske  Lena Cavallin  Ingemar Kåreholt  Thomas Andersson  Bengt Winblad  Vesna Jelic
Affiliation:1. Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden;2. Department of Neurology, University Medical Centre, Ljubljana, Slovenia;3. Department of Neurophysiology, Karolinska University Hospital, Stockholm, Sweden;4. Department of Radiology, Karolinska University Hospital, Stockholm, Sweden;5. Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden;6. Institute of Gerontology, School of Health Sciences, Aging Research Network – Jönköping (ARN-J), Jönköping University, Jönköping, Sweden;7. Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital-Huddinge, Stockholm, Sweden;8. Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
Abstract:

Objective

The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.

Methods

Patients with Alzheimer’s disease (AD, n = 58), mild cognitive impairment (MCI, n = 141), subjective cognitive impairment (SCI, n = 194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.

Results

WML (p = 0.006) and atrophy in medial temporal regions (MTA) (p = <0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p = 0.03).

Conclusions

EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.

Significance

Even the standard visually assessed EEG can complement a memory clinic diagnostic workup.
Keywords:Electroencephalography  White matter lesions  Medial temporal atrophy  Cognitive impairment  Visual analysis
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