| 不同剂量丹参酮ⅡA及丹参注射液治疗肝硬化的临床观察 |
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| 引用本文： | 刘昳,叶峰,邱根全,蔡云,孙烨.不同剂量丹参酮ⅡA及丹参注射液治疗肝硬化的临床观察[J].第四军医大学学报,2009,30(7). |
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| 作者姓名： | 刘昳 叶峰 邱根全 蔡云 孙烨 |
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| 作者单位： | 刘昳,邱根全,蔡云,孙烨,LIU Yi,QIU Gen-Quan,CAI Yun,SUN Ye(西安交通大学医学院第一附属医院中医科,陕西,西安,710061);叶峰,YE Feng(西安交通大学医学院第一附属医院传染科,陕西,西安,710061)
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| 摘 要： | 目的:探讨不同剂量丹参酮ⅡA磺酸钠注射液及其与丹参注射液治疗乙型肝炎后肝硬化疗效差别.方法:乙型肝炎后肝硬化(血瘀阻络证)患者150例,分为肝硬化代偿期(A)及肝硬化失代偿期(B)两组,每组75例.随机分为对照组,丹参(24 mL)组及丹参酮高、中、低剂量治疗组(分别为80,60,40 mg).观察各组治疗前后的临床症状、体征、肝功能指标(ALT,Tbil)、肝纤维化指标Ⅲ型前胶原(PcUl)、Ⅳ型胶原(ⅣC)、透明质酸(HA)].结果:不同剂量丹参酮均有改善临床症状,降低ALT,Tbil,以及HA,PCⅢ,ⅣC的作用(P＜0.05).其中高、中剂量组的疗效之间无差异,但优于低剂量组及丹参组(P＜0.05).代偿组与失代偿组相比,各治疗组在改善临床症状、肝功能(ALT,TBil)以及肝纤维化指标(HA,PcⅢ,ⅣC)方面,均有统计学差异(P＜0.05).结论:丹参酮疗效优于丹参注射液.二者均对肝硬化代偿期的疗效优于失代偿期.但高、中剂量丹参酮之间疗效相当.
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| 关 键 词： | 肝硬化 丹参酮ⅡA注射液 丹参注射液 投药和剂量 |
Clinical study on treatment of cirrhosis by different dosages of Salvianolic acid B and Salvia Injection |
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| LIU Yi,YE Feng,QIU Gen-Quan,CAI Yun,SUN Ye.Clinical study on treatment of cirrhosis by different dosages of Salvianolic acid B and Salvia Injection[J].Journal of the Fourth Military Medical University,2009,30(7). |
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| Authors: | LIU Yi YE Feng QIU Gen-Quan CAI Yun SUN Ye |
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| Institution: | LIU Yi1,YE Feng2,QIU Gen-Quan1,CAI Yun1,SUN Ye11Department of Traditional Chinese Medicine,2Departemnt of Infectious Diseases,First Affiliated Hospital,Medical School,Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | AIM:To find the optimal dosage of Salvianolic acid B(SAB) and Salvia Injection(SI) in treating cirrhosis with hepatitis B virus(HBV) and to compare the treatment effects between Salvianolic acid B and Salvia Injection.METHODS:One hundred and fifty cirrhosis patients with HBV were divided into compensatory group(A) and decompensated(B) cirrhosis group.In each group,the patients were randomly subdivided into large dosage SAB group(80 mg),middle dosage SAB group(60 mg),small dosage SAB group(40 mg),SI group(24... |
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| Keywords: | cirrhosis Salvianolic acid B injection salvia injection administration and dosage |
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