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2013年重庆市计划妊娠夫妇乙型肝炎血清流行病学调查
引用本文:刘俊,陈庆,李杰,杨柳,何杨. 2013年重庆市计划妊娠夫妇乙型肝炎血清流行病学调查[J]. 中华临床感染病杂志, 2014, 0(6): 506-510
作者姓名:刘俊  陈庆  李杰  杨柳  何杨
作者单位:重庆市人口和计划生育科学技术研究院技术指导所国家卫生计生委出生缺陷与生殖健康重点实验室,400020
基金项目:重庆市科学技术委员会科技攻关项目(CSTC2013ggB00001、CSTC2011ggB0113);重庆市人口和计划生育科学技术研究院基本科研业务费项目(1207)志谢本研究得到调查项目各县计生委和生殖健康中心、指导所全体同事大力支持和协助,陈和平研究员、李红主任医师、景秀主任医师、张志强主任医师参与了调查表审核工作,在此一并感谢
摘    要:目的:了解重庆市计划妊娠夫妇乙型肝炎病毒( HBV)感染情况及流行特征。方法2013年4至12月,采用多阶段分层按比例整群随机抽样方法抽取10712对计划妊娠夫妇进行问卷调查。用酶联免疫吸附试验(ELISA)检测乙型肝炎病毒表面抗原(HBsAg)和表面抗体(抗-HBs)。采用SAS 8.2软件进行统计分析,用χ2检验和χ2趋势检验对不同人群HBsAg和抗-HBs阳性率进行分析。结果21424名参检人员中, HBsAg阳性1718例,阳性率为8.02%,其中丈夫的阳性率为9.48%,妻子的阳性率为6.55%,二者差异具有统计学意义(χ^2=63.39,P<0.01);抗-HBs 阳性8967名,阳性率为41.85%,其中丈夫的阳性率为42.39%,妻子的阳性率为41.32%,二者差异无统计学意义(χ^2=2.54,P>0.05)。 HBsAg和抗-HBs阳性率均有随年龄的增长而上升的趋势(χ^2=2.98和9.83,P<0.01)。渝东南地区HBsAg阳性率最高,抗-HBs阳性率低。不同职业人群HBsAg阳性率差异大,私营业主(9.18%)最高,公职人员(6.79%)最低,抗-HBs阳性率中公职人员(49.69%)最高,农民(39.08%)最低。随着文化程度升高,HBsAg阳性率有下降趋势(χ^2=-3.33,P<0.01),抗-HBs阳性率有升高趋势(χ^2=9.73,P<0.01)。结论2013年重庆市计划妊娠人群HBV感染率仍居于较高水平,其中,渝东南地区、私营业主、高年龄计划妊娠人群是乙型肝炎疫苗接种和治疗的重点人群。

关 键 词:肝炎,乙型  血清流行病学研究  肝炎表面抗原,乙型  肝炎抗体,乙型  计划妊娠

Serological survey of hepatitis B infection among planned pregnancy couples in Chongqing in 2013
Liu Jun,Chen Qing,Li Jie,Yang Liu,He Yang. Serological survey of hepatitis B infection among planned pregnancy couples in Chongqing in 2013[J]. , 2014, 0(6): 506-510
Authors:Liu Jun  Chen Qing  Li Jie  Yang Liu  He Yang
Affiliation:(Department of Technical Guidance, Chongqing Institute for Population and Family Planning, Chongqing 400020, China)
Abstract:Objective To investigate the prevalence of hepatitis B virus infection and its epidemiological characteristics among planned pregnancy couples in Chongqing.Methods A total of 10 712 planned pregnancy couples were selected by proportionally stratified multi-stage random sampling method during April and December 2013.A questionnaire survey was performed, and enzyme linked immunosorbent assay ( ELISA) was used for hepatitis B virus surface antigen ( HBsAg ) and hepatitis B surface antibody ( anti-HBs) detection.SAS 8.2 was adopted for data process.Chi-square test and test for linear trend were performed to compare the rates of HBsAg and anti-HBs among different populations.Results Among 21 424 individuals, 1 718 (8.02%) were HBsAg positive.The positive rate of HBsAg in husbands was 9.48%, which was significantly higher than that in wives (6.55%,χ^2=63.39, P〈0.01).Anti-HBs was positive in 8 967 (41.85%) individuals, and the positive rates in husbands and wives were 42.39% and 41.32%respectively (χ^2=2.54, P>0.05).The positive rates of HBsAg and anti-HBs increased with the age (χ^2=2.98 and 9.83,P〈0.01).The highest HBsAg positive rate and lowest anti-HBs positive rate were observed among individuals of southeast of Chongqing.The positive rates of HBsAg and anti-HBs varied in people with different occupation.The highest HBsAg and anti-HBs positive rates were found in private business owners (9.18%) and public employees (49.69%) , respectively;and the lowest HBsAg and anti-HBs positive rates were found in public employees (6.79%) and farmers (39.08%), respectively.As the education level increased, HBsAg positive rate was decreasing (χ^2=-3.33, P〈0.01), and anti-HBs positive rate was increasing (χ^2=9.73, P〈0.01).Conclusions The prevalence of HBV infection is still high among planned pregnancy couples in Chongqing in the year of 2013.Vaccination and the related treatments should be enforced in population with high risk of HIV infection.
Keywords:Hepatitis B  Seroepidemiologic studies  Hepatitis B surface antigens  Hepatitis B antibodies  Planned pregnancy
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