| 伊贝沙坦对慢性肾小球肾炎患者血压和尿蛋白排泄的影响 |
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| 引用本文： | 刘宏,余济荣,刘必成,王艳丽,尹莲芳,张晓良. 伊贝沙坦对慢性肾小球肾炎患者血压和尿蛋白排泄的影响[J]. 中国临床药理学与治疗学, 2003, 8(1): 95-97 |
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| 作者姓名： | 刘宏 余济荣 刘必成 王艳丽 尹莲芳 张晓良 |
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| 作者单位： | 东南大学肾脏病研究所,附属中大医院肾脏科,南京,210009,江苏 |
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| 摘 要： | 目的：观察伊贝沙坦对慢性肾小球肾炎患的血压，尿蛋白排泄的影响。方法：27例慢性肾小球肾炎患应用伊贝沙坦治疗8wk。观察治疗前后血压，尿蛋白，肾功能，血钾，肝功能和血脂的变化。结果：与伊贝沙坦治疗前相比，治疗后血压，24h尿蛋白定量显下降，对肾功能，血钾，肝功能和血脂无影响。结论：伊贝沙坦对慢性肾小球肾炎患具有平稳显的降压，降蛋白尿作用。继而发挥肾保护作用。
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| 关 键 词： | 药效学 伊贝沙坦 慢性肾小球肾炎 高血压 蛋白尿 |
| 文章编号： | 1009-2501(2003)01-0095-03 |
| 修稿时间： | 2002-10-07 |
Influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis |
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| LIU Hong,YU Ji-Rong,LIU Bi-Cheng,WANG Yan-Li,YIN Lian-Fang,ZHANG Xiao-Liang Institute of Nephrology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing ,Jiangsu. Influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(1): 95-97 |
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| Authors: | LIU Hong YU Ji-Rong LIU Bi-Cheng WANG Yan-Li YIN Lian-Fang ZHANG Xiao-Liang Institute of Nephrology Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu |
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| Affiliation: | LIU Hong,YU Ji-Rong,LIU Bi-Cheng,WANG Yan-Li,YIN Lian-Fang,ZHANG Xiao-Liang Institute of Nephrology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,Jiangsu |
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| Abstract: | AIM: To investigate the influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis. METHODS: 27 patients with chronic glomerulonephritis were treated with irbesartan for 8 wk. Blood pressure, proteinuria, renal function, serum K+, liver function, and serum lipid were detected before and after 8 wk. RESULTS: The levels of blood pressure and 24 h proteinuria were decreased significantly (P< 0.01) 8 wk after the administration, but the renal function, serum K+, liver function and serum lipid were unchanged. CONCLUSION: Irbesartan shows a stable anti-hypertensive effect and can reduce proteinuria in patients with chronic glomerulonephritis. |
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| Keywords: | pharmacoidynamics irbesartan chronic glomerulonephritis hypertension proteinuria |
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