从“湿热瘀毒证”论治膝关节骨性关节炎急性发作期的临床研究

目的：观察膝关节骨性关节炎急性发作期从＂湿热瘀毒证＂论治的临床疗效.方法：90例急性发作期KOA患者采用随机数字表法分为2组,每组各45例,对照组给予美洛昔康分散片口服治疗,治疗组给予加味四妙勇安汤内服治疗,比较2组治疗后的总体疗效及膝关节WOMAC评分的变化.结果：治疗组总有效率为88.89%,对照组为86.67%,2组总有效率比较差异无统计学意义（P〉0.05）.治疗后2组WOMAC评分与治疗前比较均有明显下降（P〈0.01）,但治疗组的下降程度更优于对照组（P〈0.05）.结论：从＂湿热瘀毒证＂角度采用加味四妙勇安汤治疗急性发作期KOA的总体疗效与美洛昔康分散片相当,但在改善膝关节功能方面加味四妙勇安汤更具有优势,且副作用较少,值得临床进一步推广运用.

Clinical Study on the Treatment for Acute Attack of Knee Osteoarthritis from Damp heat and Stasis toxics Syndrome

Objective：To observe the clinical efficacy of the treatment for acute attack of knee osteoarthritis （KOA） from damp-heat and stasis-toxics syndrome. Methods ： A total of 90 cases of patients with KOA were randomly divided into two groups equally. The control group were treated with Meloxicam Dispersible Tablets, while the treatment group with modified SimiaoYongAn Decoction. The overall efficacy and the changes of the WOMAC scores were compared between the two groups after the treatment. Results： The total effective rate of the treatment group was 88.89%, while the control group was 86.67%. The total effective rate had no significant differences be- tween the two groups （ P 〉 0.05 ）. The WOMAC scores of the two groups were decreased significantly compared with those before （ P 〈 0.01 ）. However, the decline of the treatment group was better than the control group （P 〈 0.05 ）. Conclusion： The total effective rate of modified SimiaoYongAn Decoction was similar with Meloxicam Dispersible Tablets, but the modified SimiaoYongAn Decoction had more advantages in improving knee function and there were fewer side effects. This effective method is worth of further promotion and application.