Growth hormone and aging |
| |
| Authors: | Andrzej Bartke Ph.D. Holly Brown-Borg Beth Kinney Julie Mattison Chris Wright Steven Hauck Karen Coschigano John Kopchick |
| |
| Affiliation: | (1) Department of Physiology, Southern Illinois University, School of Medicine, Carbondale, IL, 62901-6512;(2) Department of Physiology, University of North Dakota, School of Medicine, Edwin James Research Center, 501 N. Columbia Road, Grand Forks, ND, 58202-9037;(3) Molecular Physiology and Genetics Section, National Institutes of Health, National Institute on Aging, Bethesda, MD, 20892;(4) Edison Biotechnology Institute, Ohio University, Athens, OH, 45701;(5) Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, OH, 45701 |
| |
| Abstract: | The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on growth, development, and adult body size may serve as important determinants of aging and life span, while the age-related decline in GH levels contributes to some of the symptoms of aging. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
