| Expressions of Beta-Catenin, SUFU and VEGFR-2 Proteins in MeduUoblastoma |
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| 作者姓名： | 张雄 张红梅 李昱 米粲 |
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| 作者单位： | Department of Pathology, Chongqing Medical University, Shongqing 400016 |
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| 摘 要： | Objective： to investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma. Methods： Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues. Results： the abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues, A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma. Conclusion： Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma.
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| 关 键 词： | 神经系统 颅内肿瘤 治疗方法 细胞 |
| 文章编号： | 1000-9604（2007）04-05-0299 |
| 收稿时间： | 2007-07-31 |
| 修稿时间： | 2007-10-25 |
Expressions of beta-catenin,SUFU and VEGFR-2 proteins in medulloblastoma |
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| Zhang Xiong,Zhang Hong-mei,Li Yu,Mi Can.Expressions of Beta-Catenin, SUFU and VEGFR-2 Proteins in MeduUoblastoma[J].Chinese Journal of Cancer Research,2007,19(4):299-303. |
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| Authors: | Zhang Xiong Zhang Hong-mei Li Yu Mi Can |
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| Institution: | (1) Department of Pathology, Chongqing Medical University, Shongqing, 400016, China |
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| Abstract: | Objective To investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma.
Methods Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in
33 cases of medulloblastoma and 10 normal cerebellar tissues.
Results The abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal
tissue. While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar
tissues. A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between
beta-catenin and VEGFR-2 was found in medulloblastoma.
Conclusion Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma.
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| Keywords: | Beta-cateuln VEGFR-2 SUFU Medulloblastoma |
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