| HPLC法测定咽炎口含片中辛弗林的含量 |
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| 引用本文： | 徐珽,王丽,宋毅,唐尧. HPLC法测定咽炎口含片中辛弗林的含量[J]. 中国药房, 2007, 18(21): 1645-1647 |
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| 作者姓名： | 徐珽 王丽 宋毅 唐尧 |
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| 作者单位： | 四川大学华西医院药剂科,成都市,610041 |
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| 摘 要： | 目的:建立以高效液相色谱法测定咽炎口含片中辛弗林含量的方法。方法:色谱柱为Diamonsil C_(18)(150mm×4.6mm,5μm),流动相为甲醇-磷酸二氢钾水溶液(磷酸二氢钾0.6g,十二烷基磺酸钠1.0g,冰醋酸1mL,加水至1000mL)=50:50,检测波长为225nm。结果:辛弗林进样量在0.245～2.450μg范围内与峰面积积分值线性关系良好(r=0.9995);平均回收率为93.49%,RSD=1.88%。结论:本方法准确、灵敏、重现性好、操作简便,可用于咽炎口含片的质量控制。
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| 关 键 词： | 咽炎口含片 辛弗林 高效液相色谱法 含量测定 |
| 文章编号： | 1001-0408（2007）21-1645-03 |
| 收稿时间： | 2007-01-15 |
| 修稿时间： | 2007-01-152007-04-03 |
Determination of Synephrine in Yanyan Buccal Tablets by HPLC |
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| XU Ting,WANG Li,SONG Yi,TANG Yao. Determination of Synephrine in Yanyan Buccal Tablets by HPLC[J]. China Pharmacy, 2007, 18(21): 1645-1647 |
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| Authors: | XU Ting WANG Li SONG Yi TANG Yao |
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| Abstract: | OBJECTIVE:To establish HPLC method for determination of Synephrine in Yanyan buccal tablets.METH- ODS:The stationary phase was Diamonsil C_(18)(150mm×4.6mm,5μm)column and the mobile phase was methanol-water (potassium dihydrogen phosphate 0.6g,sodium dodecylsulphate 1.0g,glacial acetic acid 1mL,add water to 1000mL)=50:50, and we set 225nm as detective wavelength.RESULTS:Within 0.245～2.450μg Synephrine had a good linearity(r=0.9995),the average recovery was 93.49% with RSD of 1.88%.CONCLUSION:The method is accurate,sensible,reproducible,simple and can be used in the quality control of Yanyan buccal tablets. |
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| Keywords: | Yanyan buccal tablets Synephrine HPLC Content determination |
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