高血压家族史与糖尿病发病的关系

探讨高血压家族史（ＨＰＨＩＳ）阳性人群与糖尿病患病的关系。方法对我国１９个省市２５岁以上的２５万人糖尿病普查中１５２２４人按有地ＨＰＨＩＳ分成阳性和阴性组，按１９９７年美国ＡＤＡ标准分为正常人（ＮＧＴ）、糖耐量低减（ＩＧＴ）、糖尿病、进行组间比较及多因素回归分析。结果（１）ＨＰＨＩＳ阳性组与阴性组比较年龄、ＢＭＩ、ＷＨＲ、血糖、血压显著增高（Ｐ〈０．０００１），ＷＪＧ ＧＭＷＷＸＥＧ ＯＹＶＫＮＩ

The relationship between family history of high hypertension and diabetes mellitus

Objective To explore the relationship between the subjects with family history of hypertension (HPHIS) and incidence of diabetes mellitus (DM). Methods Data were drawn from the national diabetes survey for 19 provinces and cities altogether 250 000 adults over 25 years old were studied. 15 224 diabetic patients were divided into two groups, positive HPHIS and negative HPHIS. According to the criteria of 1997 US ADA, the patients were also divided into normal glucose tolerance (NGT), impaired glucose tolerance (ING), and DM groups. The measurement methods for glucose, BMI, WHR, blood pressure are same as those in the study for IGT, DM in Daqing. The statistics were carried out by the comparison between groups with SAS soft ware and multiple logistic regression analysis. Results 1 The positive HPHIS group was higher in age, BMI, glucose, blood pressure than the negative HPHIS group ( P <0.000 1), but there was no significant difference in DM history between the two groups. 2 Among the NGT, IGT and DM groups, the percentage of positive HPHIS (13 86%, 19.58%, 29.20%,respectively).has significant difference ( P <0.001). 3. When multiple logistic, regression analysis for NGT and DM was taken and DM was made as the dependent variable, while age, sex, BMI, WHR, HPHIS and DM history were made as the independent variables, HPHIS was related with DM positively after above mentioned independent variables were adjusted. 4. The same result was obtained by taking multiple logistic, regression analysis for NGT and IGT. Conclusion 1. There are higher BMI, WHR, blood pressure and blood glucose in the positive HPHIS than in the negative HPHIS and there is obvious tendency of insulin resistance. 2. Positive HPHIS are positively associated with DM and IGT independently. It is suggested that the population with positive HPHIS may be an important risk factor for development of DM.