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| 缓激肽在大鼠组织瓣移植缺血后处理中影响的实验研究 | |
| 引用本文： | 曲行舟,王明一,阮敏,苏立新,张陈平. 缓激肽在大鼠组织瓣移植缺血后处理中影响的实验研究[J]. 口腔颌面外科杂志, 2010, 20(2): 95-97 |
| 作者姓名： | 曲行舟 王明一 阮敏 苏立新 张陈平 |
| 作者单位： | 上海交通大学医学院附属第九人民医院口腔颌面外科,上海市口腔医学重点实验室,上海,200011 |
| 基金项目： | 上海市卫生局青年科研项目 |
| 摘 要： | 目的:探讨缓激肽是否参与缺血后处理对组织瓣缺血再灌注损伤的保护作用。方法:60只SD大鼠随机分为缺血再灌注组、缺血后处理组和缓激肽β2受体拮抗组。检测各组之间超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondialdehyde,MDA)的浓度差,并进行统计学分析。结果:经过缺血后处理,与对照组和缓激肽β2受体拮抗组相比,SOD和MDA的含量均有显著性差异(P<0.05)。结论:缺血后处理能够减轻组织瓣缺血再灌注损伤,其机制可能与缓激肽的释放相关。 |
| 关 键 词： | 缺血后处理 缺血再灌注损伤 组织瓣 |
The Effect of Bradyldnin in Isehemic Postconditioning during Isehemic Reperfusion Injury |
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| QU Xing-zhou,WANG Ming-yi,RUAN Min,SU Li-xin,ZHANG Chen-ping. The Effect of Bradyldnin in Isehemic Postconditioning during Isehemic Reperfusion Injury[J]. Chinese Journal of Oral and Maxillofacial Surgery, 2010, 20(2): 95-97 | |
| Authors: | QU Xing-zhou WANG Ming-yi RUAN Min SU Li-xin ZHANG Chen-ping |
| Affiliation: | (Department of Oral and Maxillofacial Surgery, The Ninth People＇s Hospital, School of Stomatology, Shanghai Jiaotong University, Shanghai Key Laboratory of Stomatology Research, Shanghai 200011, China) |
| Abstract: | Objective： The aim of this study was to evaluate the effect of Bradykinin （BK） in ischemic postconditioning during ischemic reperfusion injury. Methods： 60 SD mice were divided in three groups： A, ischemic reperfusion （IR）; B, ischemic posteonditioning （IPTC）; C, bradykinin 132 receptor antagonist B1650 ＋ ischemic postconditioning （BKA＋IPTC）. The levels of malondialdehyde （MDA） and superoxide dismutase （SOD） were measured. One-way Anova was used for statistical analysis in SSPS 11.5 software package. Results： In IPTC group, MDA production decreased and SOD activities increased. There were significantly difference between IPTC and IR group （P〈0.05）. Bradykinin 132 receptor antagonist B1650 can abolish the protective effect of IPTC. Conclusion： Bradykinin involves in protection of IPTC during ischemic reperfusion injury process. |
| Keywords: | ischemic postconditioning ischemic reperfusion injury flap |
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