首页 | 本学科首页   官方微博 | 高级检索  
     


Einsatz von Bone-morphogenetic Protein-7 (BMP-7) in der Behandlung von Pseudarthrosen der oberen und unteren Extremität
Authors:Dr. M. Diefenbeck  F. Wagner  T. Mückley  G. O. Hofmann
Affiliation:1. Klinik für Unfall- und Wiederherstellungschirurgie, BG-Kliniken Bergmannstrost, Halle, Saale
4. Klinik für Unfall- und Wiederherstellungschirurgie, BG-Kliniken Bergmannstrost, Merseburger Stra?e 165, 06112, Halle, Saale
2. Berufsgenossenschaftliche Unfallklinik Murnau, Murnau
3. Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Friedrich-Schiller-Universit?t, Jena
Abstract:Bone morphogenetic proteins (BMPs) are bone growth factors, which regulate bone formation during fetal development and bone repair after injury in postfetal life. Since 1992 BMP-7 has been produced by recombinant technique (rhBMP-7). Numerous animal models and clinical trials have shown that rhBMP-7 can induce de novo bone formation in segmental defects of bones and in cases of nonunion. Since 2001 rhBMP-7 has been approved for treatment of tibial nonunion in Europe. The effect of rhBMP-7 is comparable to the clinical and radiological results achieved with bone autografts. The problem of donor site morbidity (which occurs in up to 20% of all cases) is eliminated by the use of BMP-7. Long-term results and experience in clinical practice are not yet available.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号