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PHA-ICC, ADCC and NK in patients with ANLL in CR: human fibroblastic interferon fails to increase NK-active cell frequency |
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| Authors: | L Fontana G De Rossi G De Sanctis V Bottari G Avvisati R Perricone F Mandelli |
| Affiliation: | Institute of Hematology and VI Clinical Medicine, University of Rome, “La Sapienza” Italy |
| Abstract: | PHA-ICC, ADCC and NK activity of PBL were studied in ten patients with ANLL in CR and in eighteen normal controls in the presence and absence of HFIF. No statistically significant differences were recorded among the two groups with regard to basic lymphocyte functions. Although the parameters of lymphocyte function remained analogous for those tested, the analysis at the single cell level revealed that HFIF stimulation increases the number of NK active cells and target binding cells among normals, but not in leukemic patients. |
| Keywords: | Acute non lymphoid leukemia complete remission NK activity antibody-dependent cellular cytotoxicity PHA-induced cellular cytotoxicity single cell cytotoxicity assay human fibroblast interferon target binding cells NK active cells natural killer interferon human fibroblastic interferon acute non lymphoid leukemia antibody-dependent cellular cytotoxicity chicken red blood cells phytohemagglutinin-induced cellular cytotoxicity single cell cytotoxicity assay peripheral blood lymphocytes complete remission target binding cells cytotoxic effector cells |
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