| 硒和锗对镉所致大鼠肝脏脂质过氧化的影响 |
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| 引用本文： | 杨成峰,陈学敏,常薇,杨克敌. 硒和锗对镉所致大鼠肝脏脂质过氧化的影响[J]. 华中科技大学学报(医学版), 1996, 0(4) |
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| 作者姓名： | 杨成峰 陈学敏 常薇 杨克敌 |
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| 作者单位： | 武汉同济医科大学公共卫生学院环境卫生学教研室 |
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| 基金项目： | 国家自然科学基金,卫生部青年科学研究基金 |
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| 摘 要： | 采用给大鼠腹腔注射硒（０．４ｍｇ／ｋｇ）、锗（７５ｍｇ／ｋｇ）或镉（１ｍｇ／ｋｇ）的方法，研究硒和锗对镉所致大鼠肝脏脂质过氧化作用的影响。结果表明，给大鼠连续腹腔注射镉（１ｍｇ／ｋｇ）３ｄ，可显著增强大鼠肝脏脂质过氧化作用；注射硒、锗可分别拮抗镉的脂质过氧化作用，但锗对镉所致大鼠肝微粒体、线粒体谷胱甘肽过氧化物酶活性下降没有明显影响；将硒、锗剂量减半联合应用，也能拮抗镉所致大鼠肝脏的脂质过氧化作用，表明硒和锗具有有协同抗氧化作用。
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| 关 键 词： | 硒，锗，镉中毒，脂质过氧化 |
Effect of Selenium and Germanium on Rat Liver Lipid Peroxidation Caused by Cadmium |
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| Yang Chengfeng,Chen Xuemin,Chang Wei,et al. Effect of Selenium and Germanium on Rat Liver Lipid Peroxidation Caused by Cadmium[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1996, 0(4) |
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| Authors: | Yang Chengfeng Chen Xuemin Chang Wei et al |
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| Abstract: | The effect of selenium and germanium on rat liver lipid peroxidation caued by cadmium was studied by administering i.p. Na2SeO3(0.4 mg/kg),carboxyethyl-germanium sesquioxide(Ge-132, 75 mg/kg)or/and CdCl2(l mg/kg)for 3 days.The results showed that the lipid peroxidation in rat liver caused by the injection of CdCl2 was antagonized by Na2SeO3 and Ge-132 respectively. But the decrease of activity of glutathione peroxidase(GSH-PX)in rat liver microsome and mitochondria caused by cadmium was not affected obviously by the injection of Ge-132.The combined injection of half dosages of Na2SeO3(0.2mg/kg)and Ge-132(38 mg/kg)could also antagonize the lipid peroxidation in rat liver caused by cadmium. This indicates that selenium and germanium have synergistic antioxidation. |
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| Keywords: | Selenium germanium cadmium toxicity lipid peroxidation |
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