| 冠脉介入术后气虚血瘀证与CYP2C19*2基因多态性的相关性研究 |
| |
| 引用本文： | 张娅,陈慧,李灿东,吴红霞,林云钗,洪丹丹,王建军. 冠脉介入术后气虚血瘀证与CYP2C19*2基因多态性的相关性研究[J]. 中华中医药杂志, 2011, 0(11): 2521-2524 |
| |
| 作者姓名： | 张娅 陈慧 李灿东 吴红霞 林云钗 洪丹丹 王建军 |
| |
| 作者单位： | 福建中医药大学中西医结合研究院;福建医科大学省立临床医学院;福建中医药大学中医证研究基地; |
| |
| 基金项目： | 卫生部科学研究基金-福建省卫生教育联合攻关计划项目(No.WKJ2008-2-59)~~ |
| |
| 摘 要： | 目的:探讨冠脉介入术后(PCI)气虚血瘀证与CYP2C19*2基因多态性的相关性。方法:405例行PCI成功的冠心病患者根据术后1周是否有气虚血瘀证表型分为气虚血瘀组(167例)和非气虚血瘀组(238例),抽取外周静脉血提取DNA,采用PCR-RFLP基因分析方法检测CYP2C19*2基因多态性。结果:单因素分析显示:气虚血瘀组CYP2C19*2基因突变型(GA+AA)明显高于非气虚血瘀组(χ2=15.945,P<0.001)。多因素Logistic回归分析显示:以非气虚血瘀组为参照系,调整诸混杂危险因素后,CYP2C19*2基因突变型(GA+AA)的相对危险度(OR)为2.465,95%Cl:[1.328,4.575],P=0.004。结论:冠脉介入术后CYP2C19*2基因突变患者可能易患气虚血瘀证。
|
| 关 键 词： | 经皮冠状动脉介入术 气虚血瘀证 CYP2C19*2 基因多态性 |
Relationship between qi deficiency and blood stasis syndrome after percutaneous coronary intervention and polymorphisms of CYP2C19*2 gene |
| |
| ZHANG Ya,CHEN Hui,LI Can-dong,WU Hong-xia,LIN Yun-chai,HONG Dan-dan,WANG Jian-jun. Relationship between qi deficiency and blood stasis syndrome after percutaneous coronary intervention and polymorphisms of CYP2C19*2 gene[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(11): 2521-2524 |
| |
| Authors: | ZHANG Ya CHEN Hui LI Can-dong WU Hong-xia LIN Yun-chai HONG Dan-dan WANG Jian-jun |
| |
| Affiliation: | ZHANG Ya1,CHEN Hui2,LI Can-dong3,WU Hong-xia2,LIN Yun-chai2,HONG Dan-dan2,WANG Jian-jun2(1Institute of Integrated Traditional and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China,2Provincial Clinical College of Fujian Medical University,Fuzhou 350001,3Research Base of TCM Syndrome,China) |
| |
| Abstract: | Objective:To approach the relationship between qi deficiency and blood stasis syndrome after Percutaneous Coronary Intervention and polymorphisms of CYP2C19*2 gene.Methods:405 CHD patients after receiving successful PCI were adopted in this study.Traditional Chinese Medicine(TCM) syndromes were differentiated into qi-deficiency blood-stasis type and non-qi-deficiency blood-stasis type after 7 days of standard antithrombotic therapy.All the subjects were genotyped for the polymorphisms of CYP2C19*2 by PCR-RF... |
| |
| Keywords: | Percutaneous coronary intervention Qi deficiency and blood stasis syndrome CYP2C19*2 Gene polymorphisms |
| 本文献已被 CNKI 等数据库收录！ |
|
