清化方改善糖尿病患者内皮细胞功能的临床研究

目的:观察清化方对糖尿病患者内皮细胞功能的影响,从而为运用中药早期预防糖尿病患者心血管疾病的发生提供依据。方法:采用随机平行双盲安慰剂对照的方法。将60例2型糖尿病患者随机分为两组(每组各30例),在维持其原有的治疗基础上,分别给予清化方或安慰剂,每日2次,疗程8周。观察治疗前后两组内皮依赖性血管舒张功能及其他生化指标等的改变情况。结果:与安慰剂组比较,清化方可明显改善糖尿病患者的内皮依赖性血管舒张功能肱动脉内径变化率,治疗前(13.53±4.62)%,治疗后(16.40±4.72)%,P<0.05]、提高患者的胰岛素敏感性(HOMA2 IR,P<0.05)并显著促进一氧化氮的分泌(P<0.01)。结论:①清化方可以改善糖尿病患者的内皮依赖性血管舒张功能;②清化方改善糖尿病患者血管内皮功能的机理可能与其改善患者的胰岛素抵抗、调节一氧化氮分泌有关。

Effect of Qinghua Fang on endothelial function in patients with diabetes mellitus: a random double-blind and placebo control clinical trial

Objective:To observe the effects of Qinhua Fang on endothelial function of patients with Diabetes Mellitus.Methods:A randomized,double-blind,placebo control,8-week trial was adopted.Patients with diabetes and no prior CVD events were randomized to Qinhua Fang and placebo treatment groups,and given Qinhua Fang and placebo 2 times everyday for 8 weeks.Endothelium-dependent vasodilation was assessed in brachial artery by high-resolution ultrasound technique.Blood and urine samples of subject were examined for ...