SX-1液对肝脏保存效果的形态学观察

目的 探讨新研制的肝脏灌注保存液SX-1液对保存肝脏的形态学影响.方法 使用SX-1液、威斯康星大学保存液(UW液)和高渗枸橼酸盐腺嘌呤液(HC-A液)保存大鼠肝脏2 h、8 h、24 h后行大鼠原位肝移植(OLT),于移植后6 h处死大鼠提取肝脏组织在光镜进行形态学观察,比较各组保存液对肝脏的保存效果.另外,取SX-...

Morphological observation of liver grafts preserved in SX-1 solution

Objective To observe morphological changes of experimental liver grafts preserved in SX-1 solution.Methods The rat liver grafts were preserved in SX-1 solution,University of Wisconsin（UW）solution and hypertonic citrate adenine（HC-A）solution for 2,8 and 24 hours respectively before orthotopic liver transplantation were performed.Morphological changes of liver grafts were observed when the rats survived for 6 hours after the operation.Results At 2 h and 24 h,there were no significant differences in morphological changes among the three different preservation solutions.At 8 h,the liver injury was more severe in SX-1 solution group compared with the UW solution group,but was alleviated compared with the HC-A solution group.Conclusion The SX-1 solution may replace the UW solution and HC-A solution completely for liver grafts preservation in 8 hours.