生理盐水替代HTK保存液保存活体供肾的临床研究

目的 探讨生理盐水替代组氨酸-色氨酸-酮戊二酸(histidine-tryptophan-ketoglurate,HTK)保存液对活体移植肾功能恢复的作用及可行性.方法 亲属活体供肾肾移植的患者82例,按患者意愿分为生理盐水组(29例)和HTK组(53例).生理盐水组用生理盐水作为移植肾灌注液,HTK组用HTK保存液作...

Clinical research of changing HTK solution to normal saline in living donor kidney grafts preservation

Objective To explore the feasibility of replacing histidine-tryptophan-ketoglurate （HTK） solution with normal saline in preserving living donor kidney grafts. Methods Eighty-two patients undergoing living-related donor renal transplantation were divided into normal saline group （ n = 29 ） and HTK group （ n = 53 ） according to patients＇ will. In normal saline group, normal saline was used as perfusion and preservation solution for transplant kidney, while HTK solution was used in HTK group. Reconstruction of renal circulation in recipients was made by end-to-side anastomosis of the renal vessels of donor and external iliae vessels of recipient. The renal function was monitored after transplantation, including initial urine output time, time for serum ereatinene （Set） declining to 177 μmol/L, the Scr levels at 2, 4, 24 weeks after transplantation and the urinary volume at 24 h, 48 h, 72 h after transplantation. The adverse events of transplant kidney were also observed after transplantation. Results There was no significant difference between the two groups in initial urine output time, time for Scr declining to 177 μmol/L and the urinary volume at 24 h, 48 h, 72 h after transplantation （ all in P 〉 0. 05 ）. There was also no significant difference between the two groups in Scr levels at 4 weeks after transplantation. Significant difference between two groups in Scr levels at 2 and 24 weeks was observed after transplantation, while the Scr levels were both in the normal range. There was no significant difference between two groups in the incidence rate of delayed graft function and acute rejection （ all in P 〉 0. 05 ）. Conclusion In living donor renal transplantation, it is feasible to replace HTK solution with normal saline as preservation solution and it is helpful for transplanted graft function recovery with normal saline.