沙利度胺联合地塞米松治疗多发性骨髓瘤18例疗效观察

目的观察沙利度胺联合地塞米松治疗多发性骨髓瘤的疗效及不良反应。方法35例初诊多发性骨髓瘤病人随机分成对照组（VAD方案）：长春新碱加阿霉素加地塞米松；实验组：沙利度胺加地塞米松。沙利度胺起始剂量100mg／d，每周增加100mg，最大剂量400mg／d；地塞米松40mg，第1—4天，第9-12天，第17—20天口服，30d后重复，至少治疗3个月。比较两组疗效、不良反应。结果实验组总有效率为83．33％，对照组为88．24％，两组比较差异无统计学意义（P〉0．05），副反应均可以耐受。结论沙利度胺联合地塞米松治疗多发性骨髓瘤的疗效较好，使用方便，安全性好，值得临床推广应用。

Effect of thalidomide combined with dexamethasone on multiple myeloma

Objective To explore the therapeutic and adverse effect of thalidomide combined with dexamethasone on multiple myeloma.Methods 35 patients with multiple myeloma were randomly divided into the experiment group and the control group.The experiment group received thalidomide at the starting dose of 100 mg/d,increasing by 100 mg/d every week till 400 mg/d;dexamethasone 40 mg/d,in d1-4,d9-12,d17-20 in each cycle,and the control group received chemotherapy of VAD,repeated monthly.The patients were treated consccu...