172例早产儿视网膜病变高危因素分析

目的 探讨早产儿视网膜病变(ROP)的发病情况,并研究ROP的相关危险因素.方法 选取2015年6月至2016年5月安徽省立医院新生儿科住院的出生胎龄≤34周或体质量＜2 kg的早产儿172例,根据筛查结果分为ROP组14例与无ROP组158例,对两组患儿的出生胎龄、出生体质量、性别、吸氧时间、呼吸暂停、机械通气、贫血、输血及支气管肺发育不良(BPD)等因素进行相关性分析,选择有统计学意义的因素进行多因素logistic回归分析,探讨ROP相关危险因素.结果 两组患儿出生胎龄、出生体质量、吸氧时间、呼吸暂停、机械通气、贫血、输血及BPD这8个因素差异均有统计学意义(P＜0.05).通过logistic回归分析发现出生胎龄、出生体质量、呼吸暂停、机械通气及BPD是ROP的相关危险因素(P＜0.05).结论 出生胎龄、出生体质量、呼吸暂停、机械通气及BPD是ROP的相关危险因素.

Analysis of risk factors in 172 cases of premature retinopathy

Objective To discuss the incidence of retinopathy of premature (ROP) infants and the related risk factors of ROP.Methods One hundred and seventy-two premature infants of birth gestational age ≤ 34 weeks or body mass ＜ 2 kg,hospitalized in our neonatal department between Jun 2015 and May 2016,were selected and divided into the ROP group of 14 cases and the non-ROP group of 158 cases according their screening results.The correlation of risk factors such as gestational age and body mass at birth,gender,oxygen inhaling time,apnea,mechanical ventilation,anemia,blood transfusion and broncho-pulmonary dysplasia (BPD) were analyzed within the patients of two groups,and then focusing on those factors with statistical significance,multivariate logistic regression analysis was carried out to discuss the ROP-related risk factors.Results The 8 factors of gestational age and body mass at birth,oxygen inhaling time,apnea,mechanical ventilation,anemia,blood transfusion and BPD were related to ROP development (P ＜0.05).Logistic regression analysis showed that gestational age and body mass at birth,apnea,mechanical ventilation and BPD were associated risk factors of ROP (P ＜ 0.05).Conclusion Gestational age and body mass at birth,apnea,mechanical ventilation and BPD are the ROP-related risk factors.