Pancreatoblastoma with marked elevation of serum alpha-fetoprotein |
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Authors: | Toshio Morohoshi Fumiaki Sagawa Toshiyuki Mitsuya |
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Institution: | (1) Ist Department of Pathology, Showa University School of Medicine, Hatanodai, Shinagawa-ku, Tokyo, Japan;(2) Department of pathology, Fujigaoka Hospital, Showa University, Yokohama, Japan |
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Abstract: | Summary The autopsy findings in a pancreatoblastoma in a 7-year-old Japanese girl is reported. The tumour was in the head and body of the pancreas, and was associated with diffuse carcinomatous peritonitis and hepatic and pulmonary metastases. There was marked elevation (more than 10000 ng/ml) of serum alpha-fetoprotein (AFP). Histopathologically the tumour was composed of solid epithelial elements with fibrous stroma, showing acinar arrangement, squamoid clusters and tubular structures. The epithelial elements contained numerous fine PAS positive granules in the cytoplasm. Immunocytochemical results suggested epithelial differentiation with positivity to alpha-1-antitrypsin (AAT), keratin, CA19-9, and AFP. No endocrine elements were recognized. Characteristic feature of this tumour are discussed and compared with prevoius reports. |
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Keywords: | Pancreatic neoplasm Glandular epithelial neoplasm Child Alpha fetoprotein Immunohistochemistry |
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