急性淋巴细胞白血病患儿血清铁调素水平及临床意义

目的 探索急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患儿血清铁调素(Hepcidin)水平及其临床意义.方法 选择ALL患儿30例为研究对象,随访时间截止到2020年2月,应用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检...

Serum Hepcidin levels and their clinical significance in children with acute lymphoblastic leukemia

ObjectiveTo investigate the serum levels of Hepcidin and their clinical significance in children with acute lymphoblastic leukemia(ALL).MethodsA total of 30 children with ALL were selected as the study subjects. They were followed up up to February 2020. Serum Hepcidinlevels and erythropoietin(EPO) were detected by enzyme-linked immunosorbent assay(ELISA).The blood analyzer was used to detect the hemoglobin(HGB) level of the subjects, and the Ferritin, Transferrin and C-reactive protein(CRP) levels of the subjects were detected by the special protein immunoanalyzer.The relationship between the Hepcidin level and the prognosis of ALL children was analyzed, as well as the correlation of Hepcidin with EPO, HGB, Ferritin and Transferrin.ResultsAll 30 patients with ALL were divided into two groups according to the expression level of Hepcidin. The expression level of Hepcidin was(114.4±48.63) μg/L in the high Hepcidin level group and(21.98±15.94) μg/L in the low Hepcidin level group, with significant difference(P＜0.001). The total 5-year EFS of 30 ALL patients was 77.586%. There was no statistically significant difference in survival curves between the high and low Hepcidin level groups(P＞0.05). There was a positive correlation between Hepcidin and Ferritin concentration(r=0.466， P=0.010). There was a negative correlation betweenHepcidin level and HGB content(r=-0.407， P=0.026).ConclusionSerum Hepcidin level in ALL children is not an independent factor affecting prognosis. The expression of Hepcidin in children with ALL is negatively correlated with the hemoglobin content, and positively correlated with the Ferritin concentration. Abnormal iron metabolism may be the cause of anemia in children with ALL.